Comparative effects of carbohydrate versus fat restriction on metabolic profiles,biomarkers of inflammation and oxidative stress in overweight patients with type 2 diabetic and coronary heart disease: A randomized clinical trial

Background: this study was conducted to establish the comparative effects of carbohydrate versus fat restriction on metabolic indices in type 2 diabetic (t2d) patients with coronary heart disease (chd). methods: this randomized,clinical trial was done among 56 overweight persons with t2d and chd aged 40-85 years old. the patients were randomly allocated to take either a high-carbohydrate (hc) diet (60-65% carbohydrates and 20-25% fats) (n = 28) or a restricted carbohydrate (rc) diet (43-49% carbohydrate and 36-40% fats) (n = 28) for 8 weeks to determine metabolic status. results: after 8 weeks of treatment,rc diet decreased fasting plasma glucose (fpg) (−11.5 ± 28.3 vs. +7.0 ± 26.9 mg/dl,p = 0.010) and high-sensitivity c-reactive protein (hs-crp) (−564.3 ± 1280.1 vs. +286.1 ± 1789.2 ng/ml,p = 0.040) compared with a hc diet. moreover,compared with a hc diet,rc diet increased total antioxidant capacity (tac) (+274.8 ± 111.5 vs. +20.2 ± 82.5 mmol/l,p < 0.001) and glutathione (gsh) levels (+51.6 ± 111.5 vs. −32.6 ± 88.5 μmol/l,p = 0.003). no significant alterations between the two groups were found in terms of their effect on other metabolic profiles. conclusion: rc diet in overweight t2d with chd had beneficial effects on fpg,hs-crp,tac,and gsh values. © 2017,pushpa publishing house. all rights reserved.