Applying the Framingham risk score for prediction of metabolic syndrome: the Kerman Coronary Artery Disease Risk Study, Iran

Background: there has been a few studies about the predictability of metabolic syndrome(mets) based on the framingham risk score (frs) as a tool for predicting the risk of 10-yearscardiovascular diseases (cvd) in iranian population. the aim of this study was to compare therisk stratification obtained with the frs and mets in a cohort of the iranian population.methods: in this population-based study kerman coronary artery disease risk study, iran, metswas diagnosed as defined by the revised national cholesterol education program definition criteria(atpiii) and the frs was calculated using a computer program, previously reported algorithm.results: overall, the prevalence 10-years risk of cvd for patients with mets was significantlydifferent with those without mets (74.3 vs. 86.4% for low-risk patients, 18.1 vs. 12.3% forintermediate-risk people, and 7.6 vs. 1.3% for high-risk individuals) (p < 0.001). the frequencyof intermediate-risk and high-risk for 10-year cvd in men with mets (39.5 and 18.3%,respectively) was considerably higher than women with mets (3.2 and 0.1%, respectively). usingmultiple logistic regression, the odds ratio of mets in intermediate-risk and high-risk frs groupwas 1.7 and 6.7, respectively (p < 0.001).conclusion: significant association between the presence of mets and high risk for cvdbased on frs was revealed in both men and women indicating a good concordance betweenmets and frs in predicting the risk of cvds. however, the odds ratio of the development of riskof cardiovascular events among women was higher than men with mets.