Evaluation of haptoglobin genotypes in patients with metabolic syndrome: A preliminary report

Background: haptoglobin (hp) polymorphisms have been suggested to be associated withmany pathological conditions, including cardiovascular diseases, infectious diseases, and type 2diabetes. for the first time, we aimed to investigate the possible association between hpgenotypes and metabolic syndrome (mes) in a sample of iranian subjects.methods: in this study, 291 patients with mes according to national cholesterol educationprogram-adult treatment panel iii criteria, and 284 healthy individuals have been studied. wedetermined hp genotype by polymerase chain reaction.results: the frequency of three genotype (hp1-1, hp2-1, and hp2-2) in healthy individualsand patients were 7.74, 39.7, 52.46, and 7.9, 31.61, 60.48 percent, respectively. there was nosignificant difference between the groups regarding hp genotypes. the hp2 allele was thepredominant allele in mes (76.29%) and normal subjects (72.54%).conclusion: hp polymorphisms are not risk factor for predisposition to mes in a sample of theiranian population. further studies with different ethnicities are required to validate our findings.