Comparison of N-acetylcysteine, ascorbic acid, and normal saline effect in prevention of contrast-induced nephropathy

Background: considering the crucial role of appropriate preventative strategies in reducingthe rate of contrast-induced nephropathy (cin) occurrence and its related morbidity andmortality, the effect of n-acetylcysteine (nac), ascorbic acid (aa), and normal saline (ns) wasinvestigated in the patient’s undergone coronary angiography.methods: in this clinical trial, 120 patients scheduled for elective coronary angiography with serumcreatinine (cr) level > 1.5 mg/dl or glomerular filtration rate (gfr) ? 60 selected by conveniencemethod. selected patients were allocated in three treatment groups randomly to receive oral nac(600 mg/twice daily) plus ns (100 ml/hour) (group a), oral aa (250 mg/twice daily) plus ns (100ml/hour) (group b) and ns (100 ml/hour) (group c), respectively. the occurrence of cin wasevaluated based on serum cr and gfr in three studied groups, before and after angiographyprocedure. the analysis of variance and paired t-test were used for data analysis by spss.results: the serum cr increased and gfr decreased significantly during the intervention in threegroups (p < 0.010). however, the amounts of these changes were equal between groups (p > 0.050).conclusion: the study showed that nor the addition of nac neither the addition of aa tosodium chloride infusion has more beneficial effect than hydration with sodium chloride, in theprevention of cin.