Association of chemerin levels with anthropometric indexes and C-reactive protein in obese and non-obese adolescents

Background: obesity is a low-grade chronic inflammation. this epidemic is growing indifferent age groups including adolescents. it is accompanied with a decrease in the age forincidence of obesity-related disorders. chemerin, as a chemokine and stimulator of antiinflammatoryadiponectin, links immune system, adipose tissue and inflammation. it may beuseful in predicting obesity in the hit phase of life. this study aims to assess serum chemerinand adiponectin in relation to the inflammation and obesity indices.methods: this case-control study was conducted on 82 adolescent girls, aged12-18 years. theywere categorized based on the percentiles of the body mass index (bmi).serum chemerin,adiponectin, high-sensitive c-reactive protein (hs-crp), body fat mass and its percent, waistcircumference (wc) ,hip circumference (hc) were measured; bmi and waist-to-hip ratio(whr)were calculated. data were analyzed by independent student’s t-test and pearsoncorrelation; path analysis was conducted, as well.results: we found a negative significant association between chemerin and adiponectin levelsin both obese and non-obese groups(r = -0.387, p = 0.014 vs. r = 0.362, respectively, p = 0.018).serum chemerin was higher in obese than in non-obese adolescents (441.83 ± 47.79 vs.409.30 ± 66.12 ?g /l, respectively, p = 0.012), whereas mean adiponectin level was lower inobese participants than in the other group (4.79 ± 0.94 versus 5.2 ± 0.53?g/ml, respectively, p =0.016). chemerin concentrations had significant positive correlation with hs-crp levels, bmi,wc, hc, whr, body fat mass and its percent (p < 0.05).conclusion: chemerin concentrations were associated with and adiponectin levels in obesegirl adolescents, negatively. hs-crp, bmi, wc, hc, whr, body fat mass and its’ percent werein positive relation with chemerin levels, and inverse association with serum adiponectinconcentrations. our findings suggest that chemerin can be considered as an early marker of theinflammatory process in obesity.