Cytochrome P450 2C19 polymorphism in Iranian patients with coronary artery disease

Background: the polymorphisms of cytochrome p450 2c19 (cyp2c19) gene are major prognostic factors for the response to clopidogrel therapy in patients with coronary artery diseases (cad). the cyp2c19*2 is the most important allele responsible for resistance to clopidogrel therapy. this study examined cyp2c19 gene polymorphism (cyp2c19*1 and *2) in iranian patients. methods: this cross-sectional study was performed on 43 iranian patients with cad who underwent percutaneous coronary intervention (pci) and received drug-eluted stents (des). cyp2c19 polymorphisms were assessed using real time pcr and frequency of cyp2c19*1 and cyp2c19*2 were determined, and then homo- or heterozygous state of genes was detected bymelt curve analysis method. results: forty three patients (mean age = 58.8 ± 10.0 years, 79.1% male) participated in this study. cyp2c19*1/cyp2c19*1 genotype was observed in 31 (72.1%) of participates, cyp2c19*1/cyp2c19*2 genotype in 10 (23.3%), and cyp2c19*2/cyp2c19*2 genotype in 2 patients (4.7%). the frequency of cyp2c19*2 allele in the sample was 27.9%.conclusion: this study demonstrated a high prevalence of cyp2c19*2 gene polymorphism in iranian patients. further studies with larger samples or longitudinal are required to determine the effects of this polymorphism on the prognosis of cad patients in our population.