The relationships between cortisol levels, insulin levels, and thyroid hormones with 24-h urinary sodium excretion in never treated essential hypertensive patients

Background: to study the relationship between cortisol, insulin, and thyroid hormone levels with 24-h urinary sodium (na) excretion levels in essential hypertensive patients. methods: all patients underwent history taking, physical examination, blood pressure (bp) measurement, 12 lead electocardiographic evaluation, routine urine analysis, biochemical analysis including measurement of cortisol, insulin, and thyroid hormone levels, 24-h urine collection to measure urinary na and protein excretion and creatinine clearance. results: in total, 68 newly diagnosed hypertensive patients were included. spearman correlation analysis revealed that 24-h urinary na excretion was correlated with insulin levels (ρ = −0.473, p < 0.0001), serum cortisol levels (ρ = −0.404, p= 0.0010) and creatinine clearance (ρ = 0.407, p: 0.0010). linear regression of independent factors has revealed that systolic bp (b = 0.004, ci = 0.001-0.008, p = 0.0170), body mass index (b = 0.014, ci = 0.005-0.023, p = 0.0030), being male (b = 0.077, ci = 0.001-0.153, p = 0.0480), creatinine clearance (b = 0.003, ci = 0.001-0.006, p = 0.0120) and insulin levels (b = −0.008, ci = −0.014 to −0.002, p = 0.0070) were independently related with logarithmically converted 24-h na excretion. conclusion: in conclusion, we found that insulin but not cortisol and thyroid hormone levels were independently related with 24-h urinary na excretion in newly diagnosed essential hypertensive patients.