Comparison of effects of soft margarine, blended, ghee, and unhydrogenated oil with hydrogenated oil on serum lipids: A randomized clinical trail

Background: trans fatty acids (tfas) are known as the most harmful type of dietary fats. therefore, this study was done to compare the effects of some different oils including unhydrogenated, blended, ghee, and soft magazine with hydrogenated oil on serum lipid profile of healthy adults. methods: this study was a randomized clinical trial conducted on 206 healthy participants of 20 to 60 years of age. subjects were randomly divided into 5 groups and each of them was treated with a diet containing unhydrogenated oil, ghee, blended oil, soft margarine, or hydrogenated oil for 40 days. fasting serum lipids were measured before and after the study. results: compared to hydrogenated oil, total cholesterol (tc) and triglyceride (tg) had a significant reduction in all groups, ldl-c declined in unhydrogenated oil and soft margarine groups, and apolipoprotein (apo) b only in unhydrogenated oil group (all p < 0.05). however, there was a significant enhancement in apoa of ghee oil (p < 0.001). conclusion: consuming unhydrogenated oil, ghee, soft margarine, and blended oil had some beneficial effects on serum lipids.