Evaluation of Vasodilatory Effect of Nitroglycerin in Cardioplegia Solution on PatientsUndergoing Coronary Artery Bypass Graft Surge

Introduction: this study aimed to evaluate the vasodilatory effect of nitroglycerin (ntg) incardioplegia solution on changes in troponin i and creatine phosphokinase-mb (cpk-mb) levels duringcoronary artery bypass graft (cabg) surgery.method: a randomized controlled double-blind clinical trial was performed on 44 patients who werecandidates for cabg surgery. these patients were divided into two groups. in the first group (ntg group),3 mg/kg ntg was added to the cardioplegia solution, while 10 cc placebo (distilled water) was added to thecardioplegia solution in the second group (control group). troponin i and cpk-mb levels were then assessedbefore and after the surgery.results: in this study, 72.7% and 27.3% of patients in the ntg group and 68.2% and 31.8% of patientsin the control group were male and female, respectively. in addition, 9.1% within the age range of 40-50years, 27.3% within the age range of 50-60 years, and 63.6% within the age range of more than 60 yearswere present in the ntg group. moreover, 18.2% within the age range of 40-50 years, 36.4% within theage range of 50-60 years, and 45.5% within the age range of more than 60 years were present in the controlgroup. although the mean cardiopulmonary bypass (cpb) and cross-clamp time was insignificantly higherin the ntg group compared to the control group. in addition, troponin i and cpk-mb levels after surgeryin the ntg group with the mean of 2090.68 ± 1856.07 and 97.27 ± 38.17 were significantly lower than thoseof the control group with the mean of 2697.02 ± 5586.56 and 137.95 ± 227.99, respectively (p-value <0.05).conclusion: according to the results of this study, although troponin i and cpk-mb levels increasedsignificantly after cabg surgery, this increase was significantly lower in the intervention group compared tothe control group following the administration of ntg.