Clinical and Angiographic Predictors of suboptimal Coronary Flow After PrimaryPercutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction

Introduction: this study aimed to investigate the clinical and angiographic characteristics of patientswith st-elevation myocardial infarction who experienced primary percutaneous coronary interventionfailure.method: this retrospective observational study was derived from the primary angioplasty registryof sina hospital (pars). a total of 548 consecutive patients with st-elevation myocardial infarction whounderwent primary percutaneous coronary intervention between november 2016 and january 2019 wereevaluated. percutaneous coronary intervention failure was defined as thrombolysis in myocardial infarction(timi) flow ≤ 2 or corrected timi frame count (ctfc) ≥ 28.results: the study population consisted of 458 (83.6%) males and 90 (16.4%) females with a mean ageof 59.2 ± 12.49 years. timi flow 3 was achieved in 499 (91.1%) patients after the procedure, while 49 (8.9%)patients developed timi ≤ 2. the findings showed that ctfc ≥ 28 was present in 50 (9.1%) patients, while489 (89.2%) patients had ctfc < 28. multiple regression analysis shows that age 1.04 (1.01, 1.07), durationof pain onset to first medical contact time 1.04 (1.00, 1.18), and left anterior descending artery involvement3.15 (1.21, 8.11) were independent predictors of timi ≤ 2.conclusion: even though timi ≤ 2 was uncommon among the study population, it was associated withadverse in-hospital outcomes. the results indicate that earlier emergency medical service arrival and shortertransfer time to the referral center can dramatically reduce the primary percutaneous coronary interventionfailure rate.