fibrinolytic therapy in thrombosis of mechanical valves: outcomes and complications

Introduction: valvular heart disease presents a significant and escalating global health challenge. prosthetic valve thrombosis (pvt) following surgical valve replacement is a primary cause of valve failure. the aim of this study was to ascertain the outcomes and complications of fibrinolytic therapy in patients diagnosed with pvt.method: this cross-sectional study enrolled 81 patients diagnosed with pvt who underwent fibrinolytic therapy between 2008 and 2018. streptokinase was administered to 87.6% of patients, while 12.4% received reteplase. all demographic and clinical data were gathered from the patients rsquo; medical records. the incidence of successful recovery and complications were assessed.results: the records of 81 patients (43.2% male, mean age: 51.6 ± 13.9 years) were examined. the findings revealed that 59% and 35% of the patients had mitral and aortic pvt, respectively. while 12% of the patients experienced drug complications, 90% achieved successful recovery. stroke and severe hemorrhage were complications frequently reported by the patients treated with streptokinase (8% and 4% respectively). the patients treated with reteplase demonstrated a 100% recovery rate. conversely, 89% of the patients treated with streptokinase achieved successful recovery, and 7% of the patients experienced a partial recovery.conclusion: fibrinolytic agents can serve as an effective treatment with an excellent success rate for managing pvt in patients post-surgical valve replacement.