association of angiotensin-converting enzyme gene variations with coronary artery disease in the iranian population

Background: the purpose of this study was to identify the angiotensin-converting enzyme (ace) gene (i/d) variations in cad patients and healthy controls in an iranian population (west azerbaijan province of iran).methods: this cross-sectional study included 95 cad patients and 203 healthy controls. ace i/d polymorphisms were assessed using pcr, and their frequency was determined. results: there were 298 people, 95 cad patients, and 203 controls, with an average age of 50.96±3.45 and 51.14±10.20. we discovered that the frequency of the d allele was significantly higher in cad patients than in controls (p = 0.0009). in contrast, the frequency of the i allele was significantly higher in controls than in cad patients (p = 0.0009). the d allele carriers genotypes (dd + id) were more frequent in the cad patients than in the control group (p = 0.008). the ace ii genotype-state carriers were more common in the control group than in cad patients (p = 0.0084). however, in the case of the ace id genotype, no significant differences were not found in the tested groups (p = 0.47).conclusions: these findings suggest that individuals with the ace dd genotype are predisposed to cad, whereas individuals with the ace ii genotype state are protected.