the effect of educational and encouraging interventions on anthropometric characteristics and perilipin-1 levels: tabassom study

Background: perilipin protein located in lipid droplets is involved in formation and storage of lipid in adipocytes; thus, it is considered as one of the obesity biomarkers. this study was performed to examine the effect of educational and encouragement interventions and lifestyle modifications on anthropometric characteristics and perilipin-1 level.methods: this quasi-experimental study was conducted on subsample of tabassom study. participants were 42 overweight and obese children and adolescents aged 6-18 years old and 80 overweight and obese adults aged 19-65 years old. anthropometric characteristics including weight, height, waist circumference (wc), body fat percentage (bfp), and perilipin-1 level were measured at the first and the end of study (after one year).results: after intervention, the mean of perilipin-1 decreased significantly in total children and adolescents (before vs. after: 26.79 ± 13.17 vs. 22.57 ± 8.03; p = 0.006) and girls (27.75 ± 10.51 vs. 22.00 ± 8.15; p = 0.001), but decreasing was not significant in boys. in adults, perilipin-1 levels were significantly reduced in total subjects (before vs. after: 16.19 ± 13.42 vs. 15.34 ± 11.25; p = 0.029) and men (18.02 ± 15.78 vs. 15.44 ± 10.61; p = 0.003). there was no significant difference in mean of body mass index (bmi), wc, and bfp in both groups after 12 months.conclusion: educational and encouraging interventions and lifestyle modifications could lead to decreasing perilipin-1 level in adults, children, and adolescents.