the relation between obesity and left ventricular diastolic function in young people: a cross-sectional study

Background: it has been proposed that left ventricular diastolic dysfunction (lvdd) is a possible physiological link between high body mass index (bmi) and future occurrence of heart failure (hf). the present cross-sectional study was aimed to analyze the association between bmi and lvdd by transthoracic echocardiography (tte).methods: this study was conducted from may 2017 to september 2019 in khorshid hospital of isfahan university of medical sciences, isfahan, iran. based on the calculated bmi (kg/m²), patients were divided into three groups: group 1: subjects with bmi < 25, as a normal group (n = 75), group 2: volunteer cases with 40 > bmi ≥ 30, as an obese group (n = 98), and group 3: patients with bmi ≥ 40, as a morbidly obese group (n = 100). tte was performed by a trained cardiologist and associated variables including left atrium (la) volume, e, septal e’, lateral e’,ande/e’ were assessed and also subjects were characterized as normal diastolic function, abnormal diastolic function, and inconclusive diagnosis of diastolic dysfunction (dd).results: apart from the ejection fraction (ef) and the tricuspid regurgitation velocity (trv), there was a significant difference between the other echocardiographic variables including la volume, e, septal e’, lateral e’, and e/e’ (p < 0.05). one patient with morbid obesity in our study revealed lvdd. there was no significant difference between three groups (p = 0.42).conclusion: there is no considerable relationship between obesity and lvdd. it seems that the absence of associated comorbidities such as diabetes, coronary disorders, etc. plays a crucial role in preventing lvdd, but for realistic and definitive decision, more cellular and molecular investigations and studies with larger sample size are necessary.