interleukin 10, lipid profile, vitamin d, selenium, metabolic syndrome, and serum antioxidant capacity in elderly people with and without cardiovascular disease: amirkola health and ageing project cohort-based study

Background: the age-related autoinflammation-mediated atherosclerosis is associated with some immunological, nutritional, and metabolic parameters and redox status. here, we evaluated the association of circulatory interleukin 10 (il-10) levels with lipid profile, some nutrients, and total anti-oxidant capacity in elderly people who presented cardiovascular disease (cvd) with or without metabolic syndrome (mets) and in healthy subjects. methods: in this cross-sectional case-control study, 258 sera prepared from elderly people (144 healthy and 114 patient subjects) who participated in a community-based study, the amirkola health and ageing project (ahap), were analyzed for il-10, lipid profile, vitamin d, selenium (se), antioxidant capacity, and mets. results: compared to patients, the healthy subjects exhibited higher levels of circulatory il-10 among individuals with detectable serum il-10 (p = 0.036). however, this difference was not observed when total subjects from both groups were compared, since more than 90% of those people were il-10-negative. se, vitamin d, and antioxidant levels were similar in both groups. there was a negative association between il-10 and body mass index (bmi) (p < 0.050) and an equivocal association with vitamin d levels, whereas the association between il-10 and other indicated variables was not significant. significant association was observed between mets and cvd prevalence (p < 0.001). there was a positive correlation between se and total cholesterol (tc), low-density lipoprotein cholesterol (ldl-c), and triglyceride (tg) (p < 0.010) in healthy subjects and with tc in patients (p < 0.050). conclusion: a major proportion of elderly people were serum il-10-negative, whereas independently to il-10, mets was most common in patients with cvd. weight loss may have the potential to increase il-10 levels in the elderly.