RELATIONSHIPS OF SERUM LEPTIN CONCENTRATION WITH INSULIN, GLUCOSE, HbA1c LEVELS AND INSULIN RESISTANCE IN OVERWEIGHT POST-MENOPAUSAL DIABETIC WOMEN

Background: leptin, the product of the ob gene, could have a role in the pathogenesis of obesity and non-insulin dependent diabetes mellitus (niddm). the aim of this study was to investigate relationships between serum leptin concentration and insulin, glucose, hba1c levels and insulin resistance in diabetic women.methods: we studied 45 diabetic women and 45 healthy women (controls) who aged 45-60 years and had bmi of 25-30 kg/m2. serum leptin, insulin, hba1c, fasting blood sugar and insulin resistance were determined in the two groups.results: there was a significant positive correlation between leptin and insulin (r = 0.295, p= 0.049) and insulin resistance (r = 0.329, p = 0.027) in controls but non-significant correlation between leptin and hba1c and fasting blood sugar were observed in the two groups.conclusion: this study did not document any significant relationship between serum leptin and insulin, glucose, hba1c and insulin resistance in diabetic women.