THE EFFECT OF VITAMIN E SUPPLEMENTATION ON LIPID PROFILE AND OXIDATIVE STRESS MARKERS IN HEMODIALYSIS PATIENTS

Introduction: dyslipidemia and oxidative stress are thought to be important mechanisms in pathogenesis of disease in hemodialysis patients. this study was designed to investigate the efficacy of oral vitamin e supplementation on lipid profile and oxidative stress in hemodialysis patients.methods: the study group consisted of 26 uremic patients (10 women and 16 men), 16-68 years of age undergoing maintenance hemodialysis three times a week (12 hours/week), lasting a range of 6-108 months, at vali-e-asre hospital in birjand (iran). total antioxidant capacity (tac), lipid peroxidation, cholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein levels were determined before and after oral vitamin e supplementation, 400 mg/d for 90 days.results: vitamin e supplementation caused a significant decrease in thiobarbituric acid reactive substances (tbars) level as a marker for lipid peroxidation (2.97±0.52 vs. 2.55±0.44, p<0.001) and a significant increase in plasma tac (1252±348 vs. 1398±372, p<0.01). although there was a decrease in the level of lipid profile, there were no statistically significant differences in the means of cholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein before and after vitamin e supplementation among patients.conclusion: our results indicated that oral vitamin e supplementation might be able to modify oxidative stress by an increase in tac, and a decrease in lipid peroxidation; that could be considered as a preventive strategy in hemodialysis patients