COMPARING SERUM LEPTIN AND ADIPONECTIN LEVELS IN CONTROLLED AND NON-CONTROLLED TYPE 2 DIABETES

Introduction: it has been demonstrated in recent studies that abnormal levels of adipocy-tokines may contribute to insulin resistance and type 2 diabetes. the aim of the present study was to compare serum leptin and adiponectin levels in controlled and non-controlled type 2 diabetes.methods: 117 patients with controlled and non-controlled type 2 diabetes were studied. patient, were divided into two groups based on their serum hba1c level; there were 62 patients in the controlled group (6 %< hba1c. 8%) and 55 patients in uncontrolled group (hba1c>8%).parameters like age, sex, duration of diabetes and biochemical indicators such as fasting blood sugar, hba1c, insulin resistance, leptin and adiponectin were determined.results: higher leptin and lower adiponectin levels were observed in non-controlled type 2 diabetes. the levels of fasting blood sugar and insulin resistance were significantly higher in the non-controlled group (p<0.05).conclusion: leptin and adiponectin may play an important role in the regulation of insulin sensitivity and control of type 2 diabetes.