Synthesis of Mesoporous Silica and Modified as a Drug Delivery System of Ibuprofen

In this work we synthesized of mesoporous silica nanoparticles and functionalized with 3-aminopropyltriethoxysilane to improve the loading and release of ibuprofen bonded to 3-aminopropyltriethoxysilane. sample were characterized by fourier transform infrared spectroscopy, scanning electron microscopy , x-ray diffraction, and ultraviolet-visible. the fourier transform infrared spectroscopy result demonstrate that organic group were successfully functionalized onto mesoporous silica nanoparticles. then, we investigate of the adsorption and release of ibuprofen as a drug delivery system in simulated body fluid. the result demonstrates that high adsorption capacity for drug with functionalized sample and slower drug release rate was achieved.