biosynthesis and characterization of fe3o4/cao nanoparticles and investigation of its catalytic property

The principal aim of this research is the green synthesis and application of fe3o4/cao magnetic nanoparticles (mnps) for heterocyclic reactions. fe3o4/cao mnps have been prepared using feso4 and quail eggshell waste powder in solvent-free conditions. morphology and structure of fe3o4/cao mnps were determined by ft-ir, x-ray diffraction (xrd), transmission electron microscopy (tem), and scanning electron microscopy (sem). it was used as a highly efficient catalyst for the synthesis of triazole carbohydrate derivatives. (1s, 2r, 3r, 4r)-1-(4-amino-5-mercapto-4h-1,2,4-triazol-3-yl) pentane-1,2,3,4,5-pentanol (3) was synthesized by the reaction of thiocarbohydrazide and d-gluconic acid-δ-lactone in the presence of fe3o4/cao mnps (7% mol) in ethanol under reflux conditions. compound (3) was used as an intermediate for the synthesis of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazin and thiadiazol derivatives. the assigned structure was further established by chn analyses, nmr, and ft-ir spectra. because of excellent capacity, the exceedingly simple workup, and good yield, eco-friendly catalyst fe3o4/cao mnps were proved to be a good catalyst for this reaction.