enhancing the antibacterial and anticancer activity of ciprofloxacin by encapsulating into shellac-chitosan nano particles (cnps)

This study demonstrates a preparation of a nanocarrier for drug delivery system which based on combining two natural materials shellac (sh) and chitosan (ch). the chitosan shellac nps (sh-ch nps) was loaded with ciprofloxacin drug to enhance its anticancer and antibacterial activity. the shellac – chitosan nps (sh-ch nps) size was measured using dls and its size was58.8nm ± 3.4, while the morphology of the nano compound was identified using fesem, tem techniques. we diagnosed sh-ch np synthesis by ftir, hnmr and dsc techniques. the results of mtt test showed a high inhibition rate of 55.45% for a375 melanoma cells, and a low inhibition rate for normal cells (hff) range (8.51%-32.93%)when incubated with cipro-sh-ch nps. also, the results reinforced the possibility of using ciprofloxacin loaded on chitosan – shellac nps as a promising nanocarrier with low cytotoxicity, and high activity as an antibacterial with a diameter of 40 mm with both type of positively and negatively charged bacteria.