rutin: a flavonoid precursor for synthesis of znfe2o4 nanoparticles; electrochemical study of zinc ferrite-chitosan nanogel for doxorubicin delivery

The use of core-shell nanoparticles as controlled drug delivery vehicles has proven successful, yet their production and application require costly and toxic chemicals. we hereby use a natural glycosylated flavonoid (rutin) for synthesis of a nanocarrier for doxorubicin delivery. for this target, a convenient two-step synthesis was processed including a synthesis of bio-zinc ferrite nanoparticles without n2 gas and chitosan coating (cs; bio-zincferrite@chitosan). the as-synthesized magnetic nanogel was characterized using scanning electron microscopy (sem), transmission electron microscopy (tem), fourier transformed infrared (ft-ir) spectroscopy, and electro-analytical methods including cyclic voltammetry and electrochemical impedance spectroscopies. the collapse/swell potential of the coated cs layers of the bio-nps were found to be responsible for the observed ph dependence of doxorubicin delivery. results exhibited the drug release of bio-nanogel can be induced at ph ranging from 6 to 7. therefore, capacity and efficiency parameters of the anti-cancer drug onto the nps were obtained as equal to 43.5% and 78.6%. the present work provides a simple method to fabricate smart ph-responsive nanogel for cancer therapy.