synthesize of folic acid functionalized dendritic fibrous nanosilica and its application as an efficient nanocatalyst for access to direct amidation of carboxylic acids with amines

A new nanomaterial based on folic acid functionalized dendritic fibrous nano-silica (fa-kcc-1-nh2) was synthesized and used as a recyclable solid acid and heterogeneous nanocatalyst towards efficient amidation of a variety of carboxylic acids with amines in toluene under reflux conditions. kcc-1 porous nanomaterials were produced utilizing a hydrothermal technique and next functionalized with folic acid moieties to yield kcc- 1-nh-fa nanocatalyst. the morphology, surface charge and size of kcc-1, kcc-1-nh2 and kcc-1-nh-fa nanoparticles were verified by field emission scanning electron microscope (fesem), dynamic light scattering (dls), zeta potential and transmission electron microscopy (tem), respectively. the pore size of kcc-1-nh-fa nanoparticles were moreover investigated with brunauer-emmett teller (bet) where results revealed that the surface of this nanocomposite was expanded. the synthesized kcc-1-nh-fa nanoparticles showed effective catalytic activity in amidation of carboxylic acids with amines affording in high yields (76-89%) in short period of times. moreover, other advantages of present method are easy workupcondition and recyclability of catalyst which gives economic rewards.