evaluation of biological activity of 5-fluoro-isatin thiosemicarbazone derivatives

Isatin based materials can exhibit a wide range of biological activities including antimicrobial, antiviral, antifungal, anthelmintic, antitumor, anti-hiv, anti-inflammatory, antidepressant, antioxidant, anticonvulsant, antitubercular, analgesic, and central nervous system depressant activities. in this study, four compounds containing 5-fluoro-isatin thiosemicarbazone with methoxyphenyl or methoxyphenyl in different positions and zinc complexes were evaluated based on their biological activities. compound 2 was the strongest compound affecting gramnegative bacteria compared to the other compounds. also, this compound indicated better antimicrobial activity than positive control antibiotics. besides, compound 3 was the only compound that inhibited the growth of salmonella spp. such as salmonella enteritidis atcc 13076 and salmonella typhimurium nrrle 4463. 5-fluoro-isatin thiosemicarbazone and its derivatives also showed dna protection property from moderate to good protections. among them, compound 4 displayed the highest dna binding affinity. these compounds possessed a capacity for utilization as drugs or drug additives based on their effects on bacteria strains and dna binding affinity.