Au Nanoparticle Loaded with 6-Thioguanine Anticancer Drug as a New Strategy for Drug Delivery

In this study we suggested a new strategy for drug delivery of 6-thioguanine (6-tg) as a cancer drug by loading of this thiolic drug at a surface of au nanoparticles. for this goal, we synthesized au nanoparticle (au/nps) by reduction of tetrachloroauric (iii) acid solutions by sodium borohydride and characterized au/nps by x-ray powder diffraction (xrd), dynamic light scattering (dls), ultraviolet–visible spectroscopy (uv-vis) and transmission electron microscopy (tem) methods. results showed good distribution of synthesized au nanoparticle with diameter ~ 5 nm. in the second step, we loaded 6-thioguanine with strong au-s bond by addition of this drug to au nanoparticle suspension and characterized it by uvvis method. furthermore, au nanoparticle loaded with 6-thioguanine was utilized as a new system against breast cancer cell line (mcf7). ic50 for free 6-thioguanine, unloaded au nanoparticle and 6-thioguanine loaded au nanoparticle (6-tg/au/nps) were >15.0, 80.0 and 3.5 μg/ml, respectively. the results obtained revealed high cytotoxicity effect of 6-tg/au/nps on breast cancer cell line.