TiCl2/Nano-γ-Al2O3 as a Novel Lewis Acid Catalyst for Promotion of One-pot Synthesis of 1,4-dihydropyridines

Synthesis of organic compounds using nano-catalysts is more and more attention due to the numerous advantages such as cost-effectiveness, high catalytic activity, ease of product separation, recovery of the catalyst, repeated recycling potential and good stability. in this work, ticl2/nano-γ- al2o3, as a novel type of green heterogeneous solid acid was prepared by the immobilization of ticl2 on the surface of nano-γ-al2o3 and characterized by fourier transform-infrared spectroscopy (ft-ir), x-ray diffraction (xrd), field emission-scanning electron microscope (fe-sem), energy dispersive x-ray (edx), x-ray fluorescence spectroscopy (xrf), brunauer– emmett–teller (bet) and thermal gravimetric analysis (tga). one-pot multicomponent reactions (mcrs) have been extensively studied for their simple procedures, high selectivity, and superior atom economy. the activity of ticl2/nano-γ-al2o3 was probed via the synthesis of 1,4-dihydropyridine derivatives of three components coupling reaction of aldehyde, 1,3-dicabonyl compound and ammonium acetate under solvent free condition with excellent yields in short time. the obtained 1,4-dihydropyridine derivatives were characterized by ft-ir and 1h nmr spectra.