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   Synthesis and Characterization of Novel Modified and Functionalized Silica Nano-particles for Protein Delivery Applications  
   
نویسنده davatgar mina ,mahkam mehrdad
منبع journal of nanostructures - 2018 - دوره : 8 - شماره : 2 - صفحه:209 -216
چکیده    In this study, the synthesis, characterization and controlled release behavior of new hollow silica nano particles (hsnps) and magnetic silica nano particles (msnps) were studied. magnetic silica nano particles (msnps), as drug delivery vehicles, were synthesized through the coating of fe3o4 nano-crystals with silica layers. the hsnps were obtained by removal of fe3o4 templates with hydrochloric acid and then calcinated at the high temperature. in the first step, msnps and hsnps were modified and the amine and aldehyde functional groups were introduced on the silica surfaces. in the next step, positively charged silica nano particles were synthesized through the quaternization of aminated silica nano particles (asnp) with sodium monochloroacetate (smca). following characterization, insulin was loaded into the nano particles as a model system which demonstrated a notable sustained drug release. the study shows that the hsnps could load a higher amount of drug. the release rates from the hsnps were faster than those of msnps.
کلیدواژه Drug delivery systems ,Hollow silica nano particles ,Insulin delivery ,Magnetic silica nano particles ,Modified silica nano particles
آدرس azarbaijan shahid madani university, department of chemistry, Iran, azarbaijan shahid madani university, department of chemistry, Iran
پست الکترونیکی mmahkam@yahoo.com
 
     
   
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