Synthesis and characterization of materials loaded with Ibuprofen using a TiO2 matrix obtained by sol-gel methods

Threehydroxylatedtitanium matrixloadedwith ibuprofen (tio2oh-ibu) were obtained by the sol-gel method using different molar ratio of alkoxide / water. these nanostructured materials (nm) were characterized by fourier transform infrared spectroscopy (ftir),x-ray diffraction (xrd),scanning microscopy (sem),thermogravimetric analysis (tga) and n2 adsorption isotherm. as water/alkoxide ratio increases,the specific surface areas for the composites (tio2oh-ibu) and also for references (tio2oh-ref),(without ibuprofen) decreased,being more pronounced in the latter case. by contrast,the average pore diameter increases following the same trend being more remarkable for references. finally,the analysis showed mesopores and micropores. ftir indicates the presence of hydroxyls and also water physically adsorbed,but hydroxyls free were not observed. also,higher water/alkoxide ratios enable the production of materials with negligible non-hydrolyzed alkoxide as tga and ftir results indicate. it was observed that ibuprofen incorporated to the composites corresponds to 7%w. by tga. analysis of x-ray diffraction showed that for reference (tio2oh-ref) withamolarratioalkoxide/water (1:24) the presence of anatase phase even at room temperature and that ibuprofen prevents crystallinity.therelease of the drug for these systems was analyzed in vitro,showing typical controlled release profiles for all materials studied.this behavior could be evaluated for its use in implants near the affected area or in topical forms.