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Triethylamine: An efficient N-base catalyst for synthesis of annulated uracil derivativies in aqueous ethanol
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نویسنده
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bhat a.r. ,selokar r.s. ,meshram j.s. ,dongre r.s.
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منبع
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journal of materials and environmental science - 2014 - دوره : 5 - شماره : 5 - صفحه:1653 -1657
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چکیده
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The one-pot three-component reaction for the synthesis of pyrano[2,3-d]pyrimidine derivatives has been reported via initial knoevenagel,subsequent addition and final heterocyclization of substituted aromatic aldehydes,ethylcyanoacetate and barbituric acid in aqueous ethanol solvent using triethyamine as n- base catalyst under reflux condition. the results showed that a series of aromatic aldehydes were effectively used to prepare the targeted pyrano[2,3-d]pyrimidine derivatives with good to excellent yields (69-94%) and there is no major effect on the yield of product by electron donating/withdrawing substituents. environment friendly procedure,excellent yields,inexpensive and readily available catalyst are the advantages of this procedure. all synthesized compounds were characterized by ir,1hnmr and 13cnmr spectral data.
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کلیدواژه
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Annulated uracils; Aromatic aldehydes; Barbituric acid; Ethylcyanoacetate; Triethylamine
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آدرس
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department of chemistry,rtm nagpur university, India, department of chemistry,rtm nagpur university, India, department of chemistry,rtm nagpur university,nagpur -440033,india,school of chemical sciences,north maharashtra university, India, department of chemistry,rtm nagpur university, India
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Authors
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