Evaluation of anilines models release kinetics from dosage forms using Eudragit-RL as matrix

The galenic forms able to control drug release have been prepared and investigated in this paper. in order to follow and to control the release of anilines model (ma)1-4,from spherical oral galenic forms in acidic medium,several kinetics of (ma)1-4 release have been carried out at 37°c. theoretical and experimental analysis of these kinetics were conducted in synthetic gastric fluid medium (ph=1.2),and the process was found to be controlled by transient diffusion,with constant diffusivities,for the liquid into and medical agent (ma) out of the galenic forms. according to fick's law,a mathematical treatment led to evaluate the amount of matter transferred at time (t). the present study demonstrates that it is possible to derive a direct expression for rate diffusion's of medical agent (ma).