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Validation of a method for simultaneous determination of acetaminophen and caffeine by HPLC in different pharmaceutical forms: Tablet,capsule and sachet
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نویسنده
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radi m. ,ramli y. ,el karbane m. ,marzak s. ,bougrin k. ,el bourkadi k. ,ouazzani chahdi f. ,issmaili s. ,bakhous k. ,ben ali a.
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منبع
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journal of materials and environmental science - 2016 - دوره : 7 - شماره : 12 - صفحه:4608 -4613
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چکیده
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A simple,fast,economical,accurate,precise and reproducible rp - hplc method was developed for the simultaneous estimation of acetaminophen (aaph) and caffeine (caf) in starting materialand pharmaceutical dosage forms. the method was validated in terms of specificity,linearity,precision accuracy,and robustness. the proposed method's results were found to be satisfactory and are suitable for determination of acetaminophen and caffeine for routine quality control of drugs in formulations.
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کلیدواژه
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Acetaminophen; Caffeine; HPLC; Validation
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آدرس
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national medicines control laboratory,rue lamfadalcharkaouimadinat al irfane bp 6206,rabat, Morocco, medicinal chemistry laboratory,faculty of medicine and pharmacy,mohammed v university,rabat, Morocco, national medicines control laboratory,rue lamfadalcharkaouimadinat al irfane bp 6206,rabat, Morocco, laboratoire de chimie des planteset de synthèse organique et bioorganique,faculté des sciences,mohammed v university,rabat, Morocco, laboratoire de chimie des planteset de synthèse organique et bioorganique,faculté des sciences,mohammed v university,rabat, Morocco, laboratoire de chimie des planteset de synthèse organique et bioorganique,faculté des sciences,mohammed v university,rabat, Morocco, laboratoire de chimie organique appliquée,université sidi mohamed ben abdallah,faculté des sciences et techniques, Morocco, national medicines control laboratory,rue lamfadalcharkaouimadinat al irfane bp 6206,rabat, Morocco, national medicines control laboratory,rue lamfadalcharkaouimadinat al irfane bp 6206,rabat, Morocco, national medicines control laboratory,rue lamfadalcharkaouimadinat al irfane bp 6206,rabat, Morocco
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Authors
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