Synthesis,characterization and antimicrobial activity of novel benzophenone derived 1,2,3-triazoles

A series of new benzophenone derived from 1,2,3-triazoles 3a-j was synthesized,in good yields,using copper- catalyzed alkyne-azide cycloaddition (cuaac) reaction between a variety of commercial and synthesized alkynes and 4-(azidomethyl)benzophenone. the structure of synthesized compounds were confirmed by spectral techniques 1h nmr,13c nmr,and high-resolution mass spectrometry (hrms). the prepared compounds were also tested in vitro for their antibacterial activity against gram-positive bacteria (bacillus subtilis and staphylococcus aureus),gram-negative bacteria (escherichia coli),and fungi (candida albicans). among the synthesized compounds 3a and 3b showed an interesting antimicrobial activity against all the tested strains except e. coli which showed a slightly resistance.