Phenolic investigation and potential therapeutic activities of Alectryon tomentosus (F.Muell.) radlk leaves family sapindaceae

The first phytochemical investigation of alectryon tomentosus (f.muell.) radlk leaves led to the isolation and identification of nine compounds. two phenolic acids; 4-hydroxy benzoic acid (1) and gallic acid (2) and one flavonoid aglycone; luteolin (3) were isolated from the methylene chloride extract. also another flavonoid aglycone; myricetin (4) was isolated from the ethyl acetate extract. moreover,four flavonoids glycosides; luteolin-7-o-β-glucoside (5),luteolin-7-o-β-rutinoside (6),myricetin-3-o-β-glucogside (7) and myricetin-3-o-α-rhamnoside (8) and one flavonoid aglycone; velutin (5,4'-dihydro-3',7-dimethoxy flavone) (9) were isolated from the butanol extract. their structures were established on the basis of chromatographic and spectroscopic analysis which is consistence with previous published literature. the first biological investigation of a. tomentosus leaves extracts highlighted their potential therapeutic benefits. the extracts were evaluated for their antioxidant activity by determination of blood glutathione level,anti-inflammatory activity using carrageenan induced paw edema model,analgesic activity using both hot plate technique and writhing test and antiulcer activity using corell test in albino rats. methylene chloride,ethyl acetate and butanol extracts exhibited significant antioxidant activities. both methylene chloride and aqueous extracts exhibited significant anti-inflammatory activities,whereas,methylene chloride,ethyl acetate and aqueous extracts exhibited significant analgesic and antiulcer activities. this study is valuable for understanding the potential therapeutic importance of natural flavonoids and phenolics. it is worth to mention that there are no previous phytochemical or bioactivity studies reported for a. tomentosus. © 2017.