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An efficient synthesis and antimicrobial and antifungal activities of disubstituted 3,4-dihydro-2H-1,3-thiazin-4-ones using lemon juice: A natural approach
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نویسنده
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ishak e.a. ,dehbi o. ,sabuni i. ,abdelzaher h.m.a. ,riadi y.
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منبع
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journal of materials and environmental science - 2017 - دوره : 8 - شماره : 10 - صفحه:3524 -3428
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چکیده
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An efficient and greener approach has been developed for the synthesis of 6-arylamino-5-cyano-2,3-dihydro-1,3-thiazin-4(1h)-ones,using lemon juice as a natural catalyst. it was prepared via condensation of 3-arylamino-2-cyano-3-mercaptoacrylamides with several of aldehydes. the reaction proceeded in short period of time with excellent yields. most of the synthesized compounds were tested in vitro against four bacterial strains,bacillus thuringiensis,micrococcus roseus,escherischia coli and pseudomonas aeruginosa and two strains of fungi,aspergillus niger and penicillium italicum. biological evaluation of the prepared products showed that many of them revealed promising antimicrobial activity. © 2017 university of mohammed premier.
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کلیدواژه
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3-Thiazines; A natural approach; Antimicrobial; Lemon juice; Synthesis
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آدرس
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departement of chemistry,college of science and arts,aljouf university,al qurayyat,al jouf, Saudi Arabia, departement of chemistry,college of science and arts,aljouf university,al qurayyat,al jouf, Saudi Arabia, center of olive researche,aljouf university,sakaka, Saudi Arabia, department of biology,college of science,aljouf university,sakaka, Saudi Arabia, department of pharmaceutical chemistry,college of pharmacy,sattam bin abdulaziz university,p.o. box 173,alkharj, Saudi Arabia
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Authors
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