Synthesis and investigation of antibacterial and antioxidants properties of some new 5-subsituted-8-hydroxyquinoline derivatives

A new series of 5-alkoxymethyl-8-hydroxyquinoline,5-alkyaminomethyl-8-hydroxy-quinoline,5-alkylthio-methyl-8-hydroxyquinoline were synthesized starting from 5-chloromethyl-8-hydroxyquinoline and identified using spectral analysis ir,1h nmr and 13c nmr. the newly synthesized compounds were evaluated and screened in vitro for antibacterial activities against gram-positive and gram-negative bacterial strains; the preliminary screening results showed that the series of the alkylthiomethyl-8-hydroxyquinoline present a significant antibacterial activity when compared to the standard antibiotic,nitroxoline. furthermore,the synthesized compounds demonstrated moderate antioxidant activities at a low compared with to the ascorbic acid by free radical scavenging method with 2,2-diphenyl-1-picrylhydrazyl (dpph). © 2017,university of mohammed premier oujda morocco.