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   Synthesis and investigation of antibacterial and antioxidants properties of some new 5-subsituted-8-hydroxyquinoline derivatives  
   
نویسنده el faydy m. ,djassinra t. ,haida s. ,rbaa m. ,ounine k. ,kribii a. ,lakhrissi b.
منبع journal of materials and environmental science - 2017 - دوره : 8 - شماره : 11 - صفحه:2028 -2508
چکیده    A new series of 5-alkoxymethyl-8-hydroxyquinoline,5-alkyaminomethyl-8-hydroxy-quinoline,5-alkylthio-methyl-8-hydroxyquinoline were synthesized starting from 5-chloromethyl-8-hydroxyquinoline and identified using spectral analysis ir,1h nmr and 13c nmr. the newly synthesized compounds were evaluated and screened in vitro for antibacterial activities against gram-positive and gram-negative bacterial strains; the preliminary screening results showed that the series of the alkylthiomethyl-8-hydroxyquinoline present a significant antibacterial activity when compared to the standard antibiotic,nitroxoline. furthermore,the synthesized compounds demonstrated moderate antioxidant activities at a low compared with to the ascorbic acid by free radical scavenging method with 2,2-diphenyl-1-picrylhydrazyl (dpph). © 2017,university of mohammed premier oujda morocco.
کلیدواژه 8-hydroxyquinoline; Activity; Antibacterial; Antioxidant; Characterization; In vitro; Synthesis
آدرس laboratory of agro-resources,polymers and process engineering,ibntofail university,department of chemistry,b.p. 133,kenitra, Morocco, laboratory of nutrition,health and environment,ibntofail university,department of biology,kenitra, Morocco, laboratory of separation processes,team of environment and applied chemistry,department of chemistry,b.p. 133,kenitra, Morocco, laboratory of agro-resources,polymers and process engineering,ibntofail university,department of chemistry,b.p. 133,kenitra, Morocco, laboratory of nutrition,health and environment,ibntofail university,department of biology,kenitra, Morocco, laboratory of separation processes,team of environment and applied chemistry,department of chemistry,b.p. 133,kenitra, Morocco, laboratory of agro-resources,polymers and process engineering,ibntofail university,department of chemistry,b.p. 133,kenitra, Morocco
 
     
   
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