Evaluation of Placental Mir-155-5p and Long Non-Coding Rna Sone Expression in Patients With Severe Pre-Eclampsia

It has been well documented that preeclampsia (pe) has a common etiological background, but little is known about its linkage at the molecular level.non- coding rnas are critical posttranscriptional regulators ofgene expression. this study was performed to determine whether pe is associated with alterations in placental noncoding rnas expression. microrna (mir)-155-5p and long non-coding rna (lnc)sone expression, in placentas collected sequentially from 59 patients with pe and 40 normotensive pregnancies were measured using real-time pcr.the relationship between mir-155-5p and lncsone expressions was analyzed statistically. mir- 155-5p expression was increased (fold change =1.6, p=0.04), while lncsone expression was not significantly changed (fold change =1.1, p=0.68), in placentas from patients compared with control group.mir-155-5p was upregulated in placentas from patients with pe and may have influenced enos expression. these findings indicate that mirna-155-5p may be involved in pe pathogenesis and could be a potential biomarker for this disease.