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   Association Between Helicobacter Pylori Caga, Baba2 Virulence Factors and Gastric Mucosal Interleukin-33 Mrna Expression and Clinical Outcomes in Dyspeptic Patients  
   
نویسنده Shahi Heshmat ,Reiisi Somayeh ,Bahreini Rasol ,Bagheri Nader ,Salimzadeh Loghman ,Shirzad Hedayatollah
منبع International Journal Of Molecular And Cellular Medicine - 2015 - دوره : 4 - شماره : 4 - صفحه:227 -234
چکیده    Helicobacter pylori (h. pylori) infection has been reported in more than half of the world human population. it is associated with gastric inflammation and noticeable infiltration of the immune cells to the stomach mucosa by several cytokines secretion. il-1β, il-18 have been shown to contribute to h. pylori induced gastritis, but the details of inflammation and association of virulence factors remain unclear. il-1 cytokine family has a new additional cytokine, interleukin-33 (il-33), which is contemplated to have an important role for host defense against microorganisms. h. pylori virulence factors important in gastritis risk are the cag pathogenicity island (cag-pai) and baba. this study evaluated il-33 mucosal mrna expression levels in infected and uninfected patients and its relationship with bacterial virulence factors caga, baba2 and type of gastritis. total rna was extracted from gastric biopsies of 79 h. pylori-infected patients and 51 h. pylori-negative patients. mucosal il- 33 mrna expression levels in gastric biopsies were assessed using real-time pcr. existence of virulence factors were detected by pcr. il-33 mrna expression was significantly higher in biopsies of h. pylori-infected patients compared to h. pylori-uninfected patients (p<0.0001). also there was a direct relationship between virulence factor bab-a2 and enhancement in il-33 mrna expression. furthermore, il-33 mrna expression level was significantly lower in chronic gastritis patients compared with patients with active gastritis (p<0.001). il-33 may play a crucial role in the inflammatory response and induction of the chronic gastritis and severity of inflammatory changes in the gastric mucosa.
کلیدواژه Helicobacter Pylori ,Gastritis ,Interleukin-33 ,Virulence Factor
آدرس Shahrekord University Of Medical Sciences, Cellular And Molecular Research Center, ایران, Shahrekoed University, Faculty Of Basic Science, Department Of Genetic, ایران, Shahrekord University Of Medical Sciences, Department Of Internal Medicine, ایران, Shahrekord University Of Medical Sciences, Cellular And Molecular Research Center, ایران, Shahrekord University Of Medical Sciences, Cellular And Molecular Research Center, ایران, Shahrekord University Of Medical Sciences, Cellular And Molecular Research Center, ایران
پست الکترونیکی shirzadeh@yahoo.com
 
     
   
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