Lack of Association between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis

Single-nucleotide polymorphisms (snps) in mirnasmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. our study aimed to evaluate the possible association between mirna-146a rs2910164 and mirna-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (ptb) in a sample of iranian population. this case- control study was performed on 202 ptb patients and 204 healthy individuals. genotyping was performed using tetra amplification refractory mutation system-polymerase chain reaction (t-arms-pcr). the results indicated that neither mirna-499 rs3746444 nor mirna-146a rs2910164 are associated with the risk of ptb in a sample of iranian population. larger studies with different ethnicities are required to validate our findings.