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   Hepatitis C Virus and Vaccine Development  
   
نویسنده Naderi Malihe ,Gholipour Naghmeh ,Zolfaghari Mohammad Reza ,Moradi Binabaj Maryam ,Yegane Moghadam Ahmad ,Motalleb Gholamreza
منبع International Journal Of Molecular And Cellular Medicine - 2014 - دوره : 3 - شماره : 4 - صفحه:207 -215
چکیده    The prevalence of hepatitis c virus (hcv) is approximately 3% around the world. this virus causes chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. the effectiveness of interferon-? and ribavirin therapy is about 50% and is associated with significant toxicity and cost. hence, generating new vaccines or drugs is an obligation. however, there is no vaccine available for clinical use. dna vaccines have some advantages such as producing feasibility and generating intensive cellular and humoral immune responses. activation and improvement of natural immune defense mechanisms is a necessity for the development of an effective hcv vaccine. this article discusses the current status of therapies for hepatitis c, the promising new therapies and the experimental strategies to develop an hcv vaccine.
کلیدواژه Hcv ,Dna Vaccine ,Ifn- ? ,Cellular Immune Response
آدرس Islamic Azad University, Department Of Microbiology, Qom Branch, Islamic Azad University, Qom 37185-364, Iran , ایران, Tehran, National Institute Of Genetic Engineering And Biotechnology, Department Of Molecular Genetics, Tehran, Iran , ایران, Islamic Azad University, Department Of Microbiology, Qom Branch, Islamic Azad University, Qom 37185-364, Iran , ایران, Golestan, Department Of Clinical Biochemistry, Faculty Of Medicine, Golestan University Of Medical Sciences, Golestan, Iran , ایران, Kashan, Department Of Otolaryngology, Kashan University Of Medical Sciences, Kashan, Iran , ایران, Zabol University, Department Of Biology, Faculty Of Science, University Of Zabol, Zabol, Iran , ایران
پست الکترونیکی a.yeganem@gmail.com
 
     
   
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