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   Evaluation of Pre-Treatment Serum Levels of Il-7 and Gm-Csf in Colorectal Cancer Patients  
   
نویسنده Taghipour Fard Ardekani Mehdi Mehdi ,Malekzadeh Mahyar Mahyar ,Hosseini Seyed Vahid Seyed Vahid ,Bordbar Elahe Elahe ,Doroudchi Mehrnoosh Mehrnoosh ,Ghaderi Abbas Abbas
منبع International Journal Of Molecular And Cellular Medicine - 2014 - دوره : 3 - شماره : 1 - صفحه:26 -34
چکیده    Survival of colorectal cancer (crc) patients is considerably stage-dependent; therefore, early diagnosis is a pivotal factor in decreasing mortality and morbidity associated with this cancer. gm-csf and il-7 are reported to increase in different cancers and we aimed to investigate the pre-treatment serum levels of gm-csf and il-7 in iranian patients with colorectal cancer. 127 patients (68 males and 59 females) entered this study before receiving chemotherapy or radiotherapy. a control group of 50 healthy age/sex matched individuals (27 males and 23 females) were included in the study. the serum levels of gm-csf and il-7 were measured using commercial enzyme linked immunosorbent assays. a significantly higher level of gm-csf was found in the sera of patients with colorectal cancer compared to healthy age/sex matched controls (p=0.013). however, there was no significant difference between the levels of il-7 in sera of patients and controls. we observed a significant elevation in the level of gm-csf in poorly differentiated tumors (p=0.024). also a significant correlation between lymphatic invasion and the level of gm-csf in sera of crc patients was detected (p=0.01). we found an increase of the level of il-7 in four patients presenting moderate stages of tumor concomitant with a decrease of the level of gm-csf. it can be concluded that the increase of the level of gm-csf is accompanied by crc progression in iranian patients. potential therapeutic effect of il-7 in this disease, however, needs further investigations.
کلیدواژه Colorectal Cancer ,Serum ,Gm-Csf ,Il-7
آدرس Shiraz, Shiraz Institute For Cancer Research, School Of Medicine, Shiraz University Of Medical Sciences, Shiraz, Iran, ایران, Shiraz, Shiraz Institute For Cancer Research, School Of Medicine, Shiraz University Of Medical Sciences, Shiraz, Iran, ایران, Shiraz, Colorectal Research Center, Faghihi Hospital, School Of Medicine, Shiraz University Of Medical Sciences, Shiraz, Iran, ایران, Shiraz, Shiraz Institute For Cancer Research, School Of Medicine, Shiraz University Of Medical Sciences, Shiraz, Iran, ایران, Shiraz, Shiraz Institute For Cancer Research, School Of Medicine, Shiraz University Of Medical Sciences, Shiraz, Iran, ایران, Shiraz, Shiraz Institute For Cancer Research, School Of Medicine, Shiraz University Of Medical Sciences, Shiraz, Iran, ایران
پست الکترونیکی mdoroud@sums.ac.ir
 
     
   
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