applying vasopressin-pre-conditioned human adipose mesenchymal stem cells improves heart condition after transplantation into infarcted myocardium

Transplantation of h-admscs may improve heart function after mi. avp is a neurohypophyseal hormone that reduces cardiovascular damage. this study investigated the role of avp preconditioning in the survival of mscs and their effect on myocardial repair in the mi rats. h-amscs were isolated and incubated for 3 days. the expression of oxytocin and vasopressin receptors was evaluated by real-time-pcr. forty male wistar rats were divided into 4 groups: control, sham, asc and avp-asc. ischemia was established by ligation of lad coronary artery. electrocardiography, fibrosis, angiogenesis, and apoptosis in myocardium were determined after 7 days. results showed that preconditioned mscs significantly increased cardiac function when compared with group that received non-preconditioned mscs. this was associated with significantly reduced fibrosis, increased vascular density, and decreased resident myocyte apoptosis. results indicate that avp preconditioned mscs can be consider a novel approach to management of mi.