Update on Safety and Efficacy of Hpv Vaccines: Focus on Gardasil

The human papillomavirus (hpv) is a highly contagious and prevalent virus that is primarily sexually transmitted. the gardasil® quadrivalent vaccine, the cevarix® bivalent vaccine and the gardasil® 9 nonavalent vaccine were developed to prevent the spread of hpv as well as the incidence of its associated diseases. the aim of this mini-review is to critically analyze the safety and efficacy of both the gardasil vaccines. a literature search was conducted on proquest, medline, science direct and scopus databases. more than hundred articles were scanned, and from this, 38 most relevant papers involving human studies across several countries were closely reviewed. the literature deems the gardasil® hpv vaccines to be safe and efficacious. due to the novel nature of these vaccines, long-term efficacies, as well as their associated long-term adverse effects, are yet to be confirmed. of some concern was the finding that a majority of these studies disclosed minor to major involvement with the vaccine manufacturers, and the inhibitory cost of use in developing nations. gardasil is largely considered safe to use. however, considering that these vaccines are predominantly indicated for children, further comprehensive, impartial, and long-term studies are needed to critically assess safety and efficacy.