the expression pattern and clinicopathological importance of hsa_circ_000425 in colorectal cancer

Although colorectal cancer (crc) is one of the most common cancers, the exact molecular mechanism of this cancer is not yet known. circular rnas (circrnas), a class of non-coding rnas, are newly identified and their role in the pathogenesis of various cancers has been shown. in this research, we studied the expression pattern and clinical importance of hsa_circ_000425 in crc patients. after evaluation of hsa_circ_000425 expression rate in 4 crc cell lines and 100 paired crc tissues, the potential correlation between hsa_circ_000425 expression rate and clinicopathological parameters of crc patients was analyzed. additionally, receiver operating characteristic (roc) curve was drawn to study the diagnostic value of hsa_circ_000425. a significant downregulation of hsa_circ_000425 was observed in both crc tissues and cell lines. in addition, this downregulation was significantly associated with differentiation and lymphatic metastasis. the area under the roc curve of hsa_circ_000425 was 0.839 (p < 0.001). hsa_circ_000425 may have a role in the pathogenesis of crc and might act as a potential biomarker for the diagnosis and treatment of crc; although further molecular studies must be performed in this regard.