Circulatingmir10b, Mir1 and Mir30a Expression Profiles in Lung Cancer: Possible Correlation With Clinicopathologic Characteristics and Lung Cancer Detection

<div style=textalign: justify;>circulating micrornas have been recognized as promising biomarkers for the detection of lung cancer. the objective of this study was to evaluate mir10b, mir1 and, mir30a in the plasma samples of lung cancer patients to confirm any possible relevance in the early detection of lung cancer. plasma samples from 47 nonsmallcell lung cancer patients and 41 cancerfree subjects were evaluated for selected micrornas using the realtime pcr method. to evaluate the tobacco smoking effects on micrornas expression, the studied groups were categorized into two subgroups: neversmokers and smokers. mir1/mir30a expression levels were significantly reduced in lung cancer, while the mir10b level was significantly elevated. we found that smoking had significant effects on the levels of circulating micrornas in the smokers of the cancerfree group (a significant upregulation of mir10b and significant downregulation of mir1/mir30a), and lung cancer patients (a significant elevation of mir10b). receiver operating characteristic curve analysis showed that mir10b with an area under the curve of 0.861, and mir1/mir30a with values of0.905 and 0.889 for the same parameter, could distinguish nonsmallcell lung cancer patients from cancerfree subjects. our findings demonstrated significant differences in the expression of micrornas in lung cancer and the considerable effects of smoking on micrornas levels. area under curve analysis showed that mir10b with 78% sensitivity/78% specificity, mir1 with 95% sensitivity/80% specificity and mir30a with 87% sensitivity/83% specificity,might be good (mir10b/mir30a) and excellent (mir1) markers for lung cancer detection.</div>