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   Gastric Cancer Micrornas Metasignature  
   
نویسنده Zare Ali ,Ganji Maziar ,Omrani Mir Davood ,Alipoor Behnam ,Ghaedi Hamid
منبع International Journal Of Molecular And Cellular Medicine - 2019 - دوره : 8 - شماره : 2
چکیده    & lt;div style=textalign: justify;& gt;gastric cancer (gc) is& nbsp;one of the most common types of cancer and the second leading cause of cancerassociated mortality& lt;strong& gt;. & lt;/strong& gt;identification of novel biomarkers is critical to prolonging patient survival. micrornas (mirnas) proved to play diverse roles in the physiological and pathological state in cancers including gc. herein we were aimed at performing a metaanalysis on mirna profiling studies that used microarray platforms. relevant studies were retrieved from pubmed and geo databases. we used the robust rank aggregation to perform the metaanalysis. moreover, for metasignature mirnas target genes, we performed pathway enrichment and go molecular function enrichment analysis. a total of 19 upregulated mirnas and seven downregulated mirnas in gc samples were identified. however, only three upregulated and one downregulated mirna reached statistical significance after multiple test correction. here we showed that hsamir215p, hsamir935p, hsamir253p, and hsamir375 are differentially expressed in gc samples.& lt;/div& gt;
کلیدواژه Gastric Cancer ,Microrna ,Go Enrichment ,Biomarkers
آدرس Shahid Beheshti University Of Medical Sciences, School Of Medicine, Department Of Medical Genetics, Iran, Shahid Beheshti University Of Medical Sciences, School Of Medicine, Department Of Medical Genetics, Iran, Shahid Beheshti University Of Medical Sciences, School Of Medicine, Iran; Urogenital Stem Cell Research Center, Department Of Medical Genetics, Iran, Yasuj University Of Medical Sciences, Faculty Of Para Medicine, Department Of Laboratory Sciences, Iran, Shahid Beheshti University Of Medical Sciences, School Of Medicine, Department Of Medical Genetics, Iran
پست الکترونیکی h.qaedi@sbmu.ac.ir
 
     
   
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