Association of Microrna-155 Rs767649 Polymorphism With Susceptibility To Preeclampsia

Preeclampsia (pe) is a multifactorial disorder. several studies showed that micro rnas may play a critical role in pe pathogenesis. we aimed to investigate for the first time the association of mir-155rs767649 polymorphism with pe. eighty patients with preeclampsia and 80 normal subjects were enrolled in the study. serum expression levels of mature mir-155were evaluated using real-time pcr, and mir-155 rs767649 (t/a) polymorphism was genotyped using taqman snp genotyping. there was a significant difference between the expression level of mir-155 in cases (5.86 ± 3.11) in comparison with controls (0.58 ± 0.30) (p<0.0001). also,the minor allele of rs767649 was significantly associated with increased risk of pe [recessive model: adjusted odds ratio (or) = 5.240, 95% confidence interval (ci) = (1.999-13.733),p= 0.001]. there was a significant difference between different genotypes according to expression levels of mir-155 in pe (p<0.0001) with high expression levels in ta genotype (7.10 ± 3.11 ). mir-155 may play a critical role in pe pathogenesis. the obtained data suggest that a minor allele of rs767649 might be a predisposing factor for pe.