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   Polymorphisms of Antioxidant’ Genes As A Target For Diabetes Management  
   
نویسنده Tabatabaei-Malazy Ozra ,Khodaeian Mehrnoosh ,Bitarafan Fatemeh ,Larijani Bagher ,Amoli Mahsa M.
منبع International Journal Of Molecular And Cellular Medicine - 2017 - دوره : 6 - شماره : 3 - صفحه:135 -147
چکیده    Diabetes mellitus (dm) is one of the most important health problems with increasing prevalence worldwide. oxidative stress, a result of imbalance between reactive oxygen species (ros) generation and antioxidant defense mechanisms has been demonstrated as the main pathology in dm. hyperglycemia-induced ros productions can induce oxidative stress through four major molecular mechanisms including the polyol pathway, advanced glycation end- products formation, activation of protein kinase c isoforms, and the hexosamine pathways. in the development of type 2 dm (t2dm) and its complications, genetic and environmental factors play important roles. therefore, the aim of this review was to focus on the assessment of single-nucleotide polymorphisms within antioxidant enzymes including superoxide dismutase, catalase, glutathione peroxidase, glutathione-s-transferase, nitric oxide synthase, and nad(p)h oxidase and their association with t2dm. the results would be helpful in understanding the mechanisms involved in pathogenesis of disease besides discovering new treatment approaches in management of dm.
کلیدواژه Diabetes Mellitus ,Oxidative Stress ,Antioxidants ,Polymorphism
آدرس Tehran University Of Medical Sciences, Diabetes Research Center, Endocrinology And Metabolism Clinical Sciences Institute, Endocrinology And Metabolism Research Center, ایران, Tehran University Of Medical Sciences, Endocrinology And Metabolism Clinical Sciences Institute, Endocrinology And Metabolism Research Center, ایران, Tehran University Of Medical Sciences, Endocrinology And Metabolism Clinical Sciences Institute, Endocrinology And Metabolism Research Center, ایران, Tehran University Of Medical Sciences, Endocrinology And Metabolism Clinical Sciences Institute, Endocrinology And Metabolism Research Center, ایران, Tehran University Of Medical Sciences, Endocrinology And Metabolism Molecular -Cellular Sciences Institute, Metabolic Disorders Research Center, ایران
پست الکترونیکی amolimm@tums.ac.ir
 
     
   
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