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Synthesis,biological evaluation and docking analysis of some novel quinazolin derivatives as antitumor agents
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نویسنده
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el-serwy w.s. ,mohamed n.a. ,kassem e.m.m. ,mahmoud k. ,mounier m.m.
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منبع
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iranian journal of pharmaceutical research - 2016 - دوره : 15 - شماره : 1 - صفحه:179 -196
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چکیده
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Different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3,1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g.,hydrazine hydrate and formamide. some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against human carcinoma cell lines (hepg2– mcf7– a549). the docking and the cytotoxic activity results revealed that nearly all of the compounds containing n-phenyl aniline showed significant inhibition for the three cell lines. © 2016 by school of pharmacy shaheed beheshti university of medical sciences and health services.
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کلیدواژه
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Antitumor; Benzoxazin; Cytotoxic activity; Docking analysis; Quinazolin
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آدرس
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therapeutical chemistry department,national research center,dokki,cairo, Egypt, therapeutical chemistry department,national research center,dokki,cairo, Egypt, therapeutical chemistry department,national research center,dokki,cairo, Egypt, department of pharmacognosy,national research center,cairo, Egypt, department of pharmacognosy,national research center,cairo, Egypt
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Authors
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