Secondary metabolites and biological activities of Talaromyces sp. LGT-2,an endophytic fungus from Tripterygium wilfordii

In the present study,eleven compounds (1-11) including nine alkaloids (1-9),one triterpenoid saponin (10) and one formamide (11) were isolated from talaromyces sp. lgt-2,an endophytic fungus from tripterygium wilfordi. their structures were determined based on nmr and esi-ms spectral data,as well as comparing with previous literature data. this is the first report of the isolation of alkaloids (1-9) from talaromyces genus. in the next step,all compounds were screened for their anti-monoamine oxidase,anti-acetylcholinesterase,antibacterial and antitumor activities. compound 11 showed moderate anti-monoamine oxidase activity with ic50 value of 61 μm; compounds 3,4,8 showed weaker anti-acetylcholinesterase activity; compounds 1,3,4,7,8,9 showed moderate antibacterial activities; compounds 7,8,9 showed cytotoxicity against b16 cancer cell line with inhibitory rate of 86%,82%,78%,respectively,at the concentration of 500 μg/ml. © 2016 by school of pharmacy.