Investigation of factors affecting aerodynamic performance of nebulized Nanoemulsion

This work aimed to prepare a nanoemulsion preparation containing budesonide and assess its aerodynamic behavior in comparison with suspension of budesonide. in-vitro aerodynamic performance of the corresponding micellar solution (ie. nanoemulsion preparation without oil) was investigated too. nanoemulsions of almond oil containing budesonide,as a hydrophobic model drug molecule,were prepared and optimized. then,the effect of variation of surfactant/ co-surfactant concentration on the aerodynamic properties of the nebulized aerosol was studied. the results indicated that the most physically stable formulation makes the smallest aerodynamic size. the concentration of co-surfactant was also shown to be critical in determination of aerodynamic size. furthermore,the optimized sample,with 3% w/w almond oil,20% w/w tween 80+span 80 and 2% w/w ethanol showed a smaller mmad in comparison with the commercially available suspension and the micellar solution. © 2016 by school of pharmacy.